胰岛素抵抗与帕金森病(PD)密切相关,胰高血糖素样肽-1(GLP-1)等有降糖作用的分子或能在PD中发挥神经保护作用。南昌大学陈廷涛和李胜杰与团队,近期在Bioengineering & Translational Medicine发表研究Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP-1 and modulating gut microbiota,构建了能生成GLP-1的重组整合益生菌株,并在小鼠PD模型中证实了该菌株对PD的改善效果。