专家文章 | 耿美玉

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热心肠智库专家文章 | 耿美玉

2024

CAIntegrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder

PSYCHIAT RES, 10.1016/j.psychres.2024.115804

CALow-Dose Chemotherapy Preferentially Shapes the Ileal Microbiome and Augments the Response to Immune Checkpoint Blockade by Activating AIM2 Inflammasome in Ileal Epithelial Cells

ADV SCI, 10.1002/advs.202304781

2023

CATetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis

Pharmacol Res, 10.1016/j.phrs.2023.106955

CASYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer

SIGNAL TRANSDUCT TAR, 10.1038/s41392-023-01403-w

2022

CAStructural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation

Cell Discov, 10.1038/s41421-022-00481-4

CADiscovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase

EUR J MED CHEM, 10.1016/j.ejmech.2022.114528

CAChronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis

Kidney Diseases, 10.1159/000524475

2021

CAStructure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy

J MED CHEM, 10.1021/acs.jmedchem.1c01308

CAA 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer's dementia

ALZHEIMERS RES THER, 10.1186/s13195-021-00795-7

2020

CAA phase II randomized trial of sodium oligomannate in Alzheimer's dementia

ALZHEIMERS RES THER, 10.1186/s13195-020-00678-3