过去的一年里，全球肠道领域的研究成果颇丰，取得了许多令人瞩目的进展。2024年热心肠大会之际，我们基于《热心肠日报》中收录的2023年5月以来的一年期间（2023年5月1日至2024年4月30日）发表的肠道相关领域论文，进行了多维度评选，形成了《热心肠日报》2023-2024年度榜单。
此次榜单评选涵盖了3240篇发表在363个不同期刊上的研究文献，累计影响因子达到75058.51，平均影响因子为23.17。其中，发表在Cell、Nature、Science上的文章有153篇，发表在NEJM、Lancet、JAMA上的文章有46篇。
本榜单仅代表热心肠生物技术研究院基于自身数据所做的评选，可能存在主观因素干扰等不足，仅供参考。
本篇发布“全球肠道菌群研究五大机构”。
哈佛大学
2023年5月以来代表性论文（部分）
Nature. 2023 May;617(7960):377-385.
doi: 10.1038/s41586-023-06026-3. Epub 2023 May 3.
Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance
Nature. 2023 Aug;620(7975):881-889.
doi: 10.1038/s41586-023-06409-6. Epub 2023 Aug 9.
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells
Nature. 2023 Jul;619(7971):837-843.
doi: 10.1038/s41586-023-06265-4. Epub 2023 Jun 28.
Gut microbial fatty acid isomerization modulates intraepithelial T cells
Nature. 2023 Oct;622(7983):611-618.
doi: 10.1038/s41586-023-06607-2. Epub 2023 Sep 12.
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation
Cell. 2024 Apr 11;187(8):1834-1852.e19.
doi: 10.1016/j.cell.2024.03.014. Epub 2024 Apr 2.
Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria
Cell. 2024 Jan 4;187(1):17-43.
doi: 10.1016/j.cell.2023.12.014.
Microbial transmission in the social microbiome and host health and disease
Cell. 2024 Feb 15;187(4):897-913.e18.
doi: 10.1016/j.cell.2023.12.036. Epub 2024 Jan 26.
Gut complement induced by the microbiota combats pathogens and spares commensals
Science. 2023 May 12;380(6645):619-624.
doi: 10.1126/science.adf5300. Epub 2023 May 4.
Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic
Nat Biotechnol. 2023 Nov 20.
doi: 10.1038/s41587-023-01988-1. Online ahead of print.
Spatial host–microbiome sequencing reveals niches in the mouse gut
Nat Rev Microbiol. 2023 Aug;21(8):535-550.
doi: 10.1038/s41579-023-00888-0. Epub 2023 May 3.
Roles of the gut microbiome in weight management
加州大学系统
2023年5月以来代表性论文（部分）
Nature. 2023 May;617(7961):581-591.
doi: 10.1038/s41586-023-05989-7.
Profiling the human intestinal environment under physiological conditions
Nature. 2024 Feb;626(7998):419-426.
doi: 10.1038/s41586-023-06906-8.
Reverse metabolomics for the discovery of chemical structures from humans
Cell. 2024 Feb 29;187(5):1191-1205.e15.
doi: 10.1016/j.cell.2024.01.029.
High fat intake sustains sorbitol intolerance after antibiotic-mediated Clostridia depletion from the gut microbiota
Cell. 2024 Mar 28;187(7):1801-1818.e20.
doi: 10.1016/j.cell.2024.02.019.
The underappreciated diversity of bile acid modifications
Science. 2023 Aug 11;381(6658):682-686.
doi: 10.1126/science.adf3974. Epub 2023 Aug 10.
Engineered bacteria detect tumor DNA
Science. 2023 Nov 10;382(6671):674-678.
doi: 10.1126/science.adi5536. Epub 2023 Nov 9.
Rapid bacteria-phage coevolution drives the emergence of multiscale networks
Nat Rev Microbiol. 2023 Nov;21(11):719-733.
doi: 10.1038/s41579-023-00904-3. Epub 2023 Jun 14.
The gut–liver axis and gut microbiota in health and liver disease
斯坦福大学
Nature. 2023 May;617(7961):581-591.
doi: 10.1038/s41586-023-05989-7.
Profiling the human intestinal environment under physiological conditions
Nature. 2023 Sep;621(7977):162-170.
doi: 10.1038/s41586-023-06431-8.
Mapping the T cell repertoire to a complex gut bacterial community
Cell. 2023 Jul 6;186(14):3111-3124.e13.
doi: 10.1016/j.cell.2023.05.046.
Ultra-deep sequencing of Hadza hunter-gatherers recovers vanishing gut microbes
Cell. 2023 Jun 22;186(13):2839-2852.e21.
doi: 10.1016/j.cell.2023.05.037.
Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome
Cell. 2023 Aug 3;186(16):3400-3413.e20.
doi: 10.1016/j.cell.2023.06.010.
A widely distributed gene cluster compensates for uricase loss in hominids
Cell. 2024 Jan 4;187(1):62-78.e20.
doi: 10.1016/j.cell.2023.11.018.
Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition
Nat Biotechnol. 2024 Apr;42(4):651-662.
doi: 10.1038/s41587-023-01799-4.
Phage-inclusive profiling of human gut microbiomes with Phanta
耶鲁大学
2024 Apr;628(8006):171-179.
doi: 10.1038/s41586-024-07162-0.
A host-microbiota interactome reveals extensive transkingdom connectivity
Cell. 2023 Jul 6;186(14):3095-3110.e19.
doi: 10.1016/j.cell.2023.05.024.
Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions
Science. 2023 Jul 21;381(6655):343-348.
doi: 10.1126/science.adg0727.
Emergent coexistence in multispecies microbial communities
2023 Nov 17;382(6672):766-768.
doi: 10.1126/science.adh9165.
Advancing the fitness of gut commensal bacteria
J Hepatol. 2024 Mar 28:S0168-8278(24)00225-3.
doi: 10.1016/j.jhep.2024.03.041.
Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice
康奈尔大学
2023年5月以来代表性论文（部分）
Nature. 2024 Apr;628(8006):180-185.
doi: 10.1038/s41586-024-07179-5.
Dopamine receptor D2 confers colonization resistance via microbial metabolites
Cell. 2023 Jun 8;186(12):2705-2718.e17.
doi: 10.1016/j.cell.2023.05.007.
High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients
Nat Immunol. 2023 Nov;24(11):1879-1889.
doi: 10.1038/s41590-023-01637-4.
Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19
Cell Host Microbe. 2024 May 8;32(5):661-675.e10.
doi: 10.1016/j.chom.2024.04.004.
Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology
Nat Microbiol. 2023 Jun;8(6):1039-1050.
doi: 10.1038/s41564-023-01388-w.
Widespread extinctions of co-diversified primate gut bacterial symbionts from humans
Nat Microbiol. 2024 Mar;9(3):614-630.
doi: 10.1038/s41564-024-01617-w.
Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease
