口服益生菌是缓解炎症性肠病(IBD)的有效措施,然而益生菌对胃肠道环境的敏感性及较差的肠道定植能力阻碍了其缓解效果。近日,南昌大学万昊、聂少平联合万益群教授在ACS Nano上发表文章Modified Prebiotic-Based “Shield” Armed Probiotics with Enhanced Resistance of Gastrointestinal Stresses and Prolonged Intestinal Retention for Synergistic Alleviation of Colitis,成功开发改性益生元“盾牌”武装益生菌,增强胃肠道环境抵御能力,延长肠道滞留时间,从而协同缓解结肠炎。