中草藥是老祖先的智慧結晶，用於疾病治療已有數千年之久。其效果用於治療慢性發炎疾病時特別顯著。雖然中草藥已長期被廣泛使用，然而，其潛在調控機制仍不十分清楚。腸道微生物組對於維持宿主的正常生理平衡是必須的，且腸道微生物失衡與慢性發炎相關疾病之病程有密切相關。為了持續追溯中草藥作用機制，必須結合使用微生物組相關的多體學平台來加以嚴格驗證。新一代的益生元，益生菌及後生元，將有助於未來許多慢性發炎相關疾病的預防及治療。 Traditional Chinese Medicines (TCM) that is the wisdom of our ancestors have been used to treat diseases of the folks for thousands of years, Specifically, TCM shows most efficient effects on treatment of chronic inflammation related diseases. Even though TCM has been used for such a long time, the underlying mechanisms of amelioration remain mostly not characterized. The gut microbiome has been shown to be essential for maintenance of host physiology homeostasis, and is closely related to development of chronic inflammation related diseases under dysbiosis. To continue to address the molecular mechanisms of TCM act, microbiome related multi-omics platforms together with strict validation are used. Subsequent development of prebiotics, probiotics and postbiotics is expected for better and consistent prevention or treatment of the many chronic inflammation related diseases.